Research paper on the illuminating the evolutionary and epidemic dynamics of XBB variant of G2P-Japan, co-authored by HiLung members, was published in the journal “Nature Communications” on 16 May.
The G2P-Japan has illuminated that two XBB variants (BJ.1 and BM.1.1.1) acquired high effective reproduction number (epidemic spread capacity) by genetic recombination at the receptor binding domain (RBD) of the spike protein.
This XBB variant emerged around the summer of 2022 is the first documented SARS-CoV-2 variant increasing its fitness through recombination rather than single mutations.
Our iPS cell-derived lung cells were useful for evaluating the infectivity and proliferative potential of this Omicron subvariants.
「Nature Communications」online on 16 May 2023
「Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants」
- 「The Genotype to Phenotype Japan (G2P-Japan)」
The research team led by Professor Kei Sato of the Division of Systems Virology, Institute of Medical Science, The University of Tokyo.
Several young researchers and laboratories in Japan join this collaborative effort to accelerate research.