Cell Products

Human iPSC-derived respiratory cell plates: airway & alveolar multi-well plates for pathophysiological and therapeutic R&D.

HiTrach

HiTrach

Human iPSC-derived Airway plates (cells in ALI formats)

Details
  1. Robust recapitulation of human airway morphology as well as gene/protein expression and function (Inc. Cilia), for which functionally relevant assays can be used.
  2. Reproduction of human airway pathologies well, including SARS-CoV-2 and flu infection and long-term inhalant/pollutant chemical exposure.
  3. Strong epithelial barrier, which is highly advantageous for performing TEER assay.

HiTrach-96&384

HiTrach-96&384

Human iPSC-derived Airway plates (cells in multi-well)

Details
  1. iPSC-derived airway epithelial cells are in ready-to-use multi-well format.
  2. Highly suitable for higher throughput assays such as drug screening.
  3. Great scalability with very limited well-to-well/lot-to-lot variability utilizing our proprietary iPSC-based technologies.
  4. Reproduction of human airway pathologies well, including SARS-CoV-2 and flu infection.
  5. Useful for concurrently evaluating airway toxicity of multiple toxicants.

HiAlv

HiAlv

Human iPSC-derived Alveolar plates (cells in ALI formats)

Details
  1. Recapitulate human alveolar gene/protein expression, reproducing both type 1 and 2 cells orphologically accurately.
  2. Reproduce human alveolar pathologies well, including SARS-CoV-2 infection and human lung toxicities.
REFERENCES
  1. Yin X, Riva L, Pu Y, Martin-Sancho L, Kanamune J, Yamamoto Y, et al.
    「Cell Reports」 2020; 34: 108628.
    https://www.cell.com/cell-reports/pdf/S2211-1247(20)31617-X.pdf
  2. Izumi Kimura, Daichi Yamasoba, Tomokazu Tamura, Naganori Nao, Tateki Suzuki, Yoshitaka Oda,… Kei Sato. (2022)
    「Cell」online on September 13,2022
    https://www.cell.com/cell/fulltext/S0092-8674(22)01190-4
MORE INFORMATION FOR Cell Products
  1. Multi-well plates and ALI (air-liquid interface) of airway &alveolar cells available; organoids constituted from the same cells also available if right conditions are met.
  2. Plates can be available on-demand or as subscription.
  3. Standardized unaffected control cell plates readily available.
  4. Patient-origin organoids available on demand -inquiry welcome.
  5. Airway vs Alveolar comparison (e.g., SARS-CoV-2 variants) can be conducted reliably and reproducibly.
  6. Overseas shipping available from our main lab in Kyoto, Japan.
  7. Users in top academia and pharmaceuticals worldwide.
  8. Contact us for customized/fit-for-purpose respiratory cell & organoid generation from patient-origin iPSCs.
  9. Inquiries on pricing and other details very much welcome.
    contact@hilung.com

CRO Services

Services utilizing our proprietary human iPSC-derived respiratory cells and organoids.
From investigational target identification leveraging high quality recapitulation,
to large-scale, standardized high –throughput screening based on our scalability.
Three dimensional, physiologically and morphologically relevant characteristics of our organoids
can be leveraged with our unique organoid-specific assays on offer.

Lung Toxicity profiling services

Our cells’ and organoids’ morphological manipulability, durability & scalability can be leveraged for high throughput screening.
Unaffected control cells/organoids for generic toxicity studies, as well as patient-derived and/or ene-edited cells/organoids for more specific mechanistic studies.
High-content analysis available as well, for detailed elucidation of human-relevant toxicity.

Infectious Diseases modeling

Our human iPSC-derived respiratory cells express essentially similar markers as their primary counterparts, allowing for reproducible and scalable human infection assays.
Validated markers include ACE and TMPRSS2, thus realizing a manipulable yet predictive tool with which SARS-CoV-2 infection can be efficiently and effectively assessed.
Other pathogens, including influenza and RSV, predictably infect our respiratory cells & organoids, after which we can utilize various assays.

Pulmonary Fibrosis models

Pulmonary Fibrosis models

Our alveolar organoids reproducibly demon-strate dynamic responses to pro-fibrotic and anti-fibrotic agents, leveraging the stable and unique form factor, and our 'swelling assay’.
Our antifibrotic re-expansion assay allows for non-destructive longitudinal tracking of dynamic, multi-faceted pathophysiology underlying pulmonary fibrosis.
Various conventional assays, as well as additional cellular/organoid manipulations, can be used in combination (e.g., patient-derived, genetic pulmonary fibrosis).

Cystic Fibrosis models

For further information, please contact us.

MORE INFORMATION FOR CRO Services
  1. Airway & Alveolar models in full use.
  2. Epithelium + fibroblast organoids available, with other multilineage organoids/MPS currently under development.
  3. Open to patient-derived organoid generation.
  4. Academic/non-profit discounts available; collaborative research on novel investigative efforts welcome.

Contact us for your challengeable research with our unique cells & organoids.
Inquiries on pricing and other details very much welcome.
contact@hilung.com
Thank you for your interest in our cell products and services!

PAGE TOP